Hot Review: How Non-invasive in vivo Cell Tracking Supports the Development and Translation of Cancer Immunotherapies.

Foremost, Many Congratulations to Madeleine who did a fantastic job authoring this paper!

We explain how in vivo imaging can aid the development of molecular and cell-based anti-cancer immunotherapies. We describe the principles of imaging host T-cells and adoptively transferred therapeutic T-cells as well as the value of traceable cancer cell models in immunotherapy development. Our emphasis is on in vivo cell tracking methodology, including important aspects and caveats specific to immunotherapies.

Madeleine awarded a prestigious Winston Churchill Fellowship!

Winston Churchill Fellowships are awarded to research the world’s best ideas, innovations and practices within the field of science and science education. Madeleine will be exploring environmentally sustainable laboratory practices, in the USA and share her findings with scientists and policymakers in the UK.

Many Congratulations to Madeleine!

“My goal is to drastically reduce the volume of non-essential waste sent for incineration, by introducing changes to education, policy and incentivisation. I strongly believe that we need to empower frontline scientists to make positive changes in their own workplaces. I will shape my learnings from the US, and subsequent discussions in the UK, into a series of practical recommendations that can be adopted by scientists. By collaborating directly with researchers and policymakers, we can show that high-quality research and sustainable lab practices are not mutually exclusive.” – Madeleine Iafrate

First time in vivo imaging for Rainbow & Rico

What an exciting day at the end of 2019!

After years of hard work, Rainbow finally obtained the first in vivo imaging data of her new DNA imaging compound!

And Rico, our newest team member, joined in gaining valuable insight into the routine of radionuclide in vivo imaging.

Breaking news: Candice’ latest first author paper published in Stem Cell Research!

Congratulations to Candice for her excellent work on genetic modification of differentiating iPSCs to render resultant Hepatocyte-Like Cells traceable by non-invasive whole-body in vivo imaging. We are very proud of Candice, and invite you to enjoy reading about this exciting research here!


Graphical abstract

HIGHLIGHTS

• iPSC-derived hepatocyte-like cells (HLCs) rendered traceable in vivo.
• Reproducible lentivirus-based gene transfer during the differentiation process.
• Protocol and reporter expression did not negatively impact on HLC maturation.
• Proof-of-principle shown for whole-body SPECT/CT-afforded HLC in vivo tracking.