Hot off the press: In vivo tracking of adoptively transferred regulatory T cells.

Through a great team effort we demonstrated quantitative non-invasive Treg tracking over weeks.

This addressed a fundamental need in Treg therapy development and offered a clinically compatible methodology for future Treg therapy imaging in humans.

Applying this approach, we also showed that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1+ innate immune cells.

Now available in Molecular Therapy – Methods Clinical Development

#celltherapy #transplantation #immunotherapy #imaging #molecularimaging 

Now ONLINE: Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells

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Great work by Candice, Madeleine and Adeel reviewing and explaining how non-invasive reporter gene imaging can aid the development and clinical translation of cell-based therapies. We describe the underlying principles governing non-invasive in vivo long-term cell tracking in the preclinical and clinical settings, including available imaging technologies, reporter genes, and imaging agents as well as pitfalls related to experimental design.(https://doi.org/10.1016/j.ymthe.2020.03.016)