Author: Admin

Sharing here a recent review we contributed to as part of an international consortium including the results of a multi-stakeholder survey by the HESI CT-TRACS Committee aimed at identifying areas of interest to help ensure the safe use of cellular therapeutics in the clinic.

Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective

We offer a brief overview of available technologies and then highlight the areas of interest from the survey by describing how imaging technologies can meet those needs. Areas of interest include imaging of cells over time, sensitivity of imaging modalities, ability to quantify cells, imaging cellular survival and differentiation, and safety concerns around adding imaging agents to cellular therapy protocols. 

#advancedtherapies #cellandgenetherapy #celltherapy #immunotherapy #celltracking #HESI #healthcare #emergingmarkets

… for passing her PhD viva with hardly any corrections. What a great achievement on the interface of imaging chemistry and imaging biology, and all in less than 3.5 years.

Through a great team effort we demonstrated quantitative non-invasive Treg tracking over weeks.

This addressed a fundamental need in Treg therapy development and offered a clinically compatible methodology for future Treg therapy imaging in humans.

Applying this approach, we also showed that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1⁺ innate immune cells.

Now available in Molecular Therapy – Methods Clinical Development. 

#celltherapy #transplantation #immunotherapy #imaging #molecularimaging 

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..we were scattered (with Rico and Qi on the other side of the planet)

BUT we still had great FUN!!!

We are so proud of Ines for these two excellent talks about her PhD work and about the important role of technologists in Nuclear Medicine.

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in vivo PET tracking using human NIS as a reporter gene and employing already available radiotracers

(i) enables accurate quantification of CAR-T tumour retention and

(ii) is not damaging the therapeutic cells.

Now available in Molecular Therapy: https://lnkd.in/dTQT2Me 

#celltherapy #cancerresearch #immunotherapy #immunooncology #imaging #molecularimaging #PET

Great work by Candice, Madeleine and Adeel reviewing and explaining how non-invasive reporter gene imaging can aid the development and clinical translation of cell-based therapies. We describe the underlying principles governing non-invasive in vivo long-term cell tracking in the preclinical and clinical settings, including available imaging technologies, reporter genes, and imaging agents as well as pitfalls related to experimental design.(https://doi.org/10.1016/j.ymthe.2020.03.016)

…to Laura for successfully passing her PhD viva!