What we previously took for granted, has not been possible for many many moons – and so anticipation was very high for our first in-person lab Away Day for a very long times. We went on a river cruise from the on the Thames, added a few kilometers of walk on the riverbank enjoying the fabulous weather, before arriving at the Fuller’s Griffin Brewery. The team there gave us a great tour, and it even included beer tasting in their famous Hock Cellar. We concluded with splendid pub food nearby.
Many thanks to John Isaac for organising this superb 5th international Therapeutic Tolerance Workshop in Newcastle. Thanks for inviting me to give a perspective on tracking therapeutic cells in vivo. It was scientifically fantastic, extremely inspiring, and I got to meet so many extremely new great colleagues.
Congratulations to Rico, first, for getting an oral presentation at the European Molecular Imaging Meeting 2022 (competition is larege and strong!) and, second, for a very well presented talk entitled “Cancer cell tracking for the evaluation of EGFR and PD-L1 knowckdown in NSCLC models”.
… on charaterizing the in vitro toxicity of the radioisotope Technetium-99m published in the International Journal of Molecular Sciences.
This was a rather multidisciplinary endeavour spanning biochemitry, fluorescence microscopy, whole-body imaging, and dosimetry. Ines got later awarded a Student Prize at the British Nuclear Medicine Society for this. Very well done by Ines, who drove the project, and also very well done by everyone contributing to this important paper. The data presented will further guide the safe use of Tc-99m during imaging and other applications.
Proudly reporting that a significant part of Yasmin’s PhD work was recently published in the Eur. J. Immunol. Have a look at her work entitled “Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive” which informs on IL-10 co-expression in CAR-Treg cells providing an additional advantage to their intended suppressive capacity. Yasmin’s work provides an important proof-of-principle for this cell engineering approach for next-generation Treg therapy in transplantation.
Many congratulations to Ben for successfully passing his viva today and soon putting crossing the ultimate finishing line for his studies for a PhD degree at King’s.
Rainbow’s viva happened already back in August, but now the Award has been confirmed after completion of all formalities. Rainbow’s project, co-supervised by Dr Gilbert Fruhwirth and Prof Ramón Vilar, focused on building a probe that allowed tumour imaging at a whole-body and microscopic level, while selectively delivering a highly cytotoxic agent into tumours.
Proud to see our latest work published by the British Journal of Cancer: https://lnkd.in/djxJhGQ.
We proposed a migrastatic drug development pipeline. As part of the pipeline, we provide a new traceable spontaneous melanoma metastasis model for in vivo quantification of metastasis and anti-metastatic effects by non-invasive imaging.
This was a fantastic team effort between Vicky Sanz Moreno‘s team at Barts Cancer Institute and ourselves at King’s College London – Massive THANKS to everybody involved!
#cancerresearch #metastasis #drugdiscovery #imaging #celltracking #skincancer
Sharing here a recent review we contributed to as part of an international consortium including the results of a multi-stakeholder survey by the HESI CT-TRACS Committee aimed at identifying areas of interest to help ensure the safe use of cellular therapeutics in the clinic.
Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective
We offer a brief overview of available technologies and then highlight the areas of interest from the survey by describing how imaging technologies can meet those needs. Areas of interest include imaging of cells over time, sensitivity of imaging modalities, ability to quantify cells, imaging cellular survival and differentiation, and safety concerns around adding imaging agents to cellular therapy protocols.
#advancedtherapies #cellandgenetherapy #celltherapy #immunotherapy #celltracking #HESI #healthcare #emergingmarkets
The Fruhwirth Lab 