Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective

Sharing here a recent review we contributed to as part of an international consortium including the results of a multi-stakeholder survey by the HESI CT-TRACS Committee aimed at identifying areas of interest to help ensure the safe use of cellular therapeutics in the clinic.

Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective

We offer a brief overview of available technologies and then highlight the areas of interest from the survey by describing how imaging technologies can meet those needs. Areas of interest include imaging of cells over time, sensitivity of imaging modalities, ability to quantify cells, imaging cellular survival and differentiation, and safety concerns around adding imaging agents to cellular therapy protocols. 

#advancedtherapies #cellandgenetherapy #celltherapy #immunotherapy #celltracking #HESI #healthcare #emergingmarkets

Hot off the press: In vivo tracking of adoptively transferred regulatory T cells.

Through a great team effort we demonstrated quantitative non-invasive Treg tracking over weeks.

This addressed a fundamental need in Treg therapy development and offered a clinically compatible methodology for future Treg therapy imaging in humans.

Applying this approach, we also showed that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1+ innate immune cells.

Now available in Molecular Therapy – Methods Clinical Development

#celltherapy #transplantation #immunotherapy #imaging #molecularimaging 

Now ONLINE: Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells

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Great work by Candice, Madeleine and Adeel reviewing and explaining how non-invasive reporter gene imaging can aid the development and clinical translation of cell-based therapies. We describe the underlying principles governing non-invasive in vivo long-term cell tracking in the preclinical and clinical settings, including available imaging technologies, reporter genes, and imaging agents as well as pitfalls related to experimental design.(https://doi.org/10.1016/j.ymthe.2020.03.016)