Rainbow’s PhD work published…

…in Bioorganic & Medicinal Chemistry. Many Congratulations to Rainbow!!!

DNA can form non-canonical structures including so-called G4 DNA quadruplexes. Their formation in vivo has been associated with a range of biological functions, hence they have been identified as potential drug targets, and G4 DNA-binding drug candidates have been developed. Here, we report the functionalisation of one of these well-established G4 DNA binders (based on a square planar platinum(II)-salphen complex) with two different radiolabelled complexes. An ¹¹¹In-conjugate was successfully used by Rainbow to assess its in vivo distribution in a mouse tumour model using single-photon emission computed tomography (SPECT) imaging. Rainbow’s work highlighted the accumulation of this Pt-salphen-¹¹¹In conjugate in the tumour.